Citrinin Mycotoxicosis in Laying He ...

Citrinin Mycotoxicosis in Laying Hens

Citrinin is nephrotoxic and causes diuresis in poultry.  Laying hens fed citrinin-appended diets develop wet droppings, but egg production and body weight are no affected. Citrinin fed to laying hens for 6 weeks is distributed to skeletal muscle, egg yolk, and egg white.


  • Wet droppings
  • Diuresis
Causing Agents
Penicillium and Aspergillus produce citrinin toxin, a natural contaminant of corn, rice, and other cereal grains. Penicillium citrinum occurs mainly in Canada and northern Europe, suggesting toxigenic Penicillium may have a competitive advantage in cooler climates. Penicillium citrinum in 1931 was recognized antibacterial and antibiotic properties preceded the discovery of nephrotoxicity. Citrinin is heat sensitive.
Affected Systems/Organs
Urinary System Kidney
Mainly Affects
Wet Litter/Manure. Faeces. Wet droppings.
Removal of the citrinin toxin allows a return to normal renal function. Toxic feed should be removed and replace with unadulterated feed. Detoxification using mycotoxin-binders holds promise for using contaminated of feedstuff by fungi capable of producing mycotoxin is quite common. Detoxification using mycotoxin-binder holds promise for using contaminated feeds while preventing intoxication. Inorganic mineral absorbents or binders including various clays (bentonite clay), soils, and zeolites. Zeolites reduce the effects of aflatoxin and cyclopiazonic acid. Addition of and organic aluminosilicate adsorbent to the feed.
Suggested Actions
  • Can be confirmed with clinical signs and gross lesions
  • Can be managed with feed additives, off-the-shelf medications

Impact on Egg quality


Impact on Liveability


Impact on Production


Overall Economic Impact


Y.M. Saif.2008.Disease of Poultry. 12th Edition. pag 1210

Mark Pattison, Paul F. McMullin, Janet M. Bradbury. Dennis J. Alexander. 2008. Poultry Diseases. 6th Edition.

Paul McMullin. 2004. A pocket Guide to Poultry Health and Disease. First Edition.

Steven Leeson, John D. Summers. 2008. Commercial Poultry Nutrition. Third Edition.

Donald D. Bell, Williams D. Weaver. 2009.  Commercial Chicken Meat and Egg Production. Fifth Edition.

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